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Bolandiol

Category:
CAS:
19793-20-5
FOB Price:
10 USD/Gram
Min. Order:
10Gram
Supply Ability:
1000 Kilogram/Month
Port:
shenzhen
Payment Terms:
T/T,Western Union,MoneyGran
Purity:
99%
  • Product Detail
Quick Details
  • CAS:
  • 19793-20-5
  • FOB Price:
  • 10 USD/Gram
  • Min. Order:
  • 10Gram
  • Supply Ability:
  • 1000 Kilogram/Month
  • Port:
  • shenzhen
  • Payment Terms:
  • T/T,Western Union,MoneyGran
  • Aliase:
  • Purity:
  • 99%
  • Usage:
  • Appearance:
  • Brand:
  • RAWSGEAR
  • Updatetime
  • 23 Sep 2019 09:50
Delivery Information

100% Special safe shipment with 100% resend policy

Product Description

Bolandiol is a synthetic anabolic steroid that increases lean body mass and bone mineral density without significantly stimulating the sexual accessory glands of adult male rats. Since bolandiol inhibits the production of gonadotropin and endogenous testosterone (T), we investigated its mechanism of action. We compared the efficacy of boranediol with T,5α-dihydrotestosterone (DHT), 19-nortestosterone (19-NT) and estradiol (E(2)) in vitro and in vivo. Compared with other androgens, Bolandiol has lower affinity for recombinant androgen receptor (AR), and recombinant human progesterone receptor (PR-A, PR-B) and estrogen receptors (ERalpha and β-) 1) has low but measurable affinity. ). Functional agonist activity is assessed in AR, PR or ER mediated transcription assays. Bolandiol is irritating in all of these assays, but only 4-9% is as effective as T, DHT and 19-NT AR, with 1% efficacy comparable to PR progesterone, 3% and 1% Efficacy was effective with E(2) via ERalpha or ERbeta, respectively. In immature ovariectomized rats, bolandiol is equivalent to T in stimulating the growth of levator ani muscle, but not as effective as T in stimulating accessory gland growth. Bolandiol also stimulated an increase in uterine weight in immature female rats, which was not partially blocked by ICI 182,780, but was not aromatized in vitro by recombinant human aromatase. Simultaneous treatment with the dual 5α-reductase inhibitor dutasteride did not inhibit bolandiol's stimulation of the sex glandular weight compared to T. Since bolandiol exhibits tissue selectivity in vivo, it may act through AR, PR and/or ER.

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  • About Us
Contact Us
Company:
Wuhan Shuiyixing Pharmaceutical Chemical Co., Ltd.
Country:
China (Mainland)
Name:
Ms.Mandy
Telephone:
86-132-64734726
Fax:
86-132-
City:
wuhan
Address:
gaoxinjishuyuan
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